How psychotherapy changes the brain in panic disorder and social anxiety

A new investigation published in the current issue of Psychotherapy and Psychosomatics disclosed important brain mechanisms for the action of psychotherapy in panic disorder. Patients with panic disorder (PD) and agoraphobia (AG) often suffer from other mental disorders especially social anxiety disorder. Neurally, both disorders exhibit substantial neurofunctional overlap within the defensive system network. Those networks might be crucial in social anxiety due to the high relevance of detecting social cues.

Fear conditioning serves as a model for the development, maintenance and treatment of anxiety disorders via CBT. It involves several neural pathways that have been partly identified as pathophysiological correlates of panic, agoraphobia and social anxiety. The aim of this study was to investigate whether CBT specifically tailored to target panic disorder and agoraphobia, also targets clinical and neurofunctional correlates of secondary social anxiety.

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